2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-174298
    Ipriflavone metabolites IV
    Ipriflavone metabolites IV is a metabolite of Ipriflavone (HY-N0094).
    Ipriflavone metabolites IV
  • HY-126194
    Tolcapone 3-β-D-glucuronide
    Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone (HY-17406) and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.
    Tolcapone 3-β-D-glucuronide
  • HY-123001
    Nomelidine
    Nomelidine is the metabolite of Zimelidine (HY-118835), that exhibits antidepressant and analgesic properties.
    Nomelidine
  • HY-150333
    MMB-ICA
    MMB-ICA is a metabolite of MMB-CHMICA.
    MMB-ICA
  • HY-W585873
    Bupivacaine N-oxide hydrochloride
    Bupivacaine N-oxide hydrochloride is a metabolite of Bupivacaine (HY-B0405). Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
    Bupivacaine N-oxide hydrochloride
  • HY-111211
    CP-457493
    CP-457493 is an Erlotinib (HY-50896) metabolite. CP-457493 can be detected in plasma.
    CP-457493
  • HY-W588209
    Oxychlordane
    Oxychlordane ( (±) -Oxychlordane) is a major metabolite of the insecticide chlordane.
    Oxychlordane
  • HY-W741106
    5-Hydroxybuspirone
    5-Hydroxybuspirone is a metabolite of the anti-anxiety agent Buspirone (HY-B1115A).
    5-Hydroxybuspirone
  • HY-124041
    p-Hydroxybestatin
    p-Hydroxybestatin is an active metabolite of Bestatinc (HY-B0134) that can be found in serum from muscular dystrophic patients and from healthy subjects dosed with Bestatin.
    p-Hydroxybestatin
  • HY-100583AR
    (±)-Equol (Standard)
    (±)-Equol (Standard) is the analytical standard of (±)-Equol. This product is intended for research and analytical applications. (±)-Equol is the racemate of equol. (±)-equol exhibits EC50s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.
    (±)-Equol (Standard)
  • HY-W587411
    2Carboxy-MMHP
    Mono[2-(carboxymethyl)hexyl] phthalate (MCHP) is a metabolite of Di-(2-ethylhexyl)phthalate (DEHP). DEH is an endocrine disrupting chemical that is widely used as the major plasticizer.
    2Carboxy-MMHP
  • HY-134999
    10-Hydroxywarfarin
    10-Hydroxywarfarin, a metabolite of (R)-(+)-Warfarin (HY-W015998 ), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC50s of 1.6 µM and 80 ng/mL, respectively.
    10-Hydroxywarfarin
  • HY-111811
    Homomangiferin
    Homomangiferin is mangiferin monomethyl ether. Homomangiferin has important medicinal properties and is widely used to relieve many symptoms, for example coughing and asthma.
    Homomangiferin
  • HY-B1986R
    p,p'-DDE (Standard)
    p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women.
    p,p'-DDE (Standard)
  • HY-W014277
    2,6-Diisopropylnaphthalene
    2,6-Diisopropylnaphthalene is a substituted naphthalene compound, metabolite precursor and potato sprout inhibitor. 2,6-Diisopropylnaphthalene is metabolized in rats only via oxidation of its isopropyl chains, producing five major unconjugated urinary metabolites, glucuronide conjugates of these metabolites, while a small amount of the parent drug is excreted in urine. 2,6-Diisopropylnaphthalene inhibits sprouting of stored potato tubers; when used alone, it only provides a short-term sprout-inhibiting effect.
    2,6-Diisopropylnaphthalene
  • HY-W008614S1
    Lansoprazole sulfone-13C6
    Lansoprazole sulfone (AG-1813)-13C6 is 13C labeled Lansoprazole sulfone (HY-W008614). Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H+, K+-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
    Lansoprazole sulfone-<sup>13</sup>C<sub>6</sub>
  • HY-W343578
    Fenthoxon
    Fenthoxon is a fenthion metabolite. Fenthion is an organophosphate insecticide.
    Fenthoxon
  • HY-135580
    Raloxifene Bismethyl Ether
    Raloxifene Bismethyl Ether is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent.
    Raloxifene Bismethyl Ether
  • HY-116074
    FUB-PB-22 3-carboxyindole metabolite
    		99.15%
    FUB-PB-22 3-carboxyindole metabolite is the main metabolite of FDU-PB-22 and FUB-PB-22.
    FUB-PB-22 3-carboxyindole metabolite
  • HY-W709579
    AB-CHMINACA metabolite M5A
    		Control
    AB-CHMINACA metabolite M5A is a metabolite of AB-CHMINACA in the liver.
    AB-CHMINACA metabolite M5A
Cat. No. Product Name / Synonyms Application Reactivity